STUDY THE ASSOCIATION OF 25-HYDROXY VITAMIN D LEVEL IN PATIENTS WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY

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Dr. Sangeeta Rai
Dr. Anubhuti Gupta
Dr. Jigyasa Singh

Abstract

Background: Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, is characterized by pruritus, elevated serum bile acids, and elevated transaminases in late second and third trimester of pregnancy. A low amount of vitamin D in serum is associated with intrahepatic cholestasis during pregnancy.


Objective: To study the correlation of 25(OH) vitamin D3 in ICP with normal pregnancy, and neonatal outcomes in patients with ICP.


Materials and methods: The study is a case-control study, conducted with pregnant women coming to OPD or labour room of Sir Sunderlal Hospital, BHU. Serum levels of 25(OH) Vitamin D3 were measured using a CLIA method; (Roche Diagnostics International Ltd., USA). Neonatal outcomes were also studied.


Result: The mean SGPT, SGOT, total bilirubin, and alkaline phosphatase levels were significantly raised in ICP group as com- pared to control group. The mean serum bile acid was significantly high in ICP group as compared to control group (p<0.001).


Conclusion: Serum 25(OH) vitamin D3 levels are significantly low in cases of ICP as compared to normal pregnancy. Serum 25(OH) vitamin D3 levels in ICP are inversely correlated by meconium staining, a major indicator of foetal distress.

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