PREGNANCY OUTCOME IN A PRIMIGRAVIDA WITH CYSTIC FIBROSIS HAVING POOR LUNG FUNCTION

Abstract

Cystic Fibrosis (CF), an autosomal recessive monogenic disorder is caused by mutation in cystic fibrosis transmembrane regulator (CFTR) protein. It causes unusually thick and viscous secretions in lung, gastrointestinal and biliary tract. Its prevalence is high in Caucasian population and relatively uncommon in Indian population. This report presents a case of 34-year-old primigravida who is known case of CF with background diagnosis of CF induced diabetes, Beta-thalassemia trait and asthma. During her admission for acute exacerbation of respiratory infections, incidental pregnancy was detected. Inspite of having poor lung function i.e. forced expiratory volume in 1 second (FEV1) was below 50%, she had a successful pregnancy outcome.

Keywords: Pregnancy; Cystic Fibrosis, Lung function