Main Article Content
Objective: To compare the success rates, incomplete abortion / continuing pregnancy rates, rate of complications and systemic side effects of three different time regimens (4h, 24h, 48h) of misoprostol after 200 mg oral mifepristone.
Method: A total of 91 patients were recruited in the study from Gynaecology OPD. There was no significant difference in mean age, gravidity and parity in the women in the three groups. All of them received oral mifepristone 200 mg. Women were then randomized in three groups to receive misoprostol. They received misoprostol 800 μg at 4h, 24h and 48h respectively. Follow up was scheduled for first week, second week and fourth week. Those who did not abort by the end of first week were given second dose of misoprostol 800 μg.
Results: Complete abortion rate in one week in the groups I, II and III were 90%, 93.5% and 90.0% respectively which improved to 96.6%, 100% and 100% in groups I, II and III respectively after second dose of misoprostol given after one week. Side effects such as diarrhoea, nausea and cramps were least in women in group II.
Conclusion: Women in group II had least side effects where misoprostol was given 24h after mifepristone without decline in success rates.
Keywords: Medical abortion, Mifepristone, Misoprostol, Three time regimen