ROLE OF MAGNESIUM SULPHATE AS TOCOLYTIC IN PRE-TERM AND ITS EFFECT ON MATERNAL HEALTH

Abstract

Background: Preterm birth is defined as babies born alive before the compleon of 37 weeks of pregnancy. It is a common cause of neonatal morbidity and mortality. Almost one million children die each year due to complicaons of preterm birth. Magnesium sulphate causes direct inhibion of acon potenals in myometrial muscle cells, reduces acetylcholine release at the myoneural juncon, and thus inhibits smooth muscle contraclity.

Objecve: To study the role of magnesium sulphate as tocolyc in preterm and its effect on maternal health.

Materials and methods: This study was conducted on 100 indoor antenatal paents with preterm labour pains from 28-36 weeks of gestaon in the Department of Obstetrics and Gynecology, Kanpur. Paents were divided into two groups: Group I included pregnant women who were given magnesium sulphate (Study group, n=50), Group II included pregnant women who were not given magnesium sulphate (Control group, n=50).

Results: Majority of cases in both the groups delivered a er 24 hours. On evaluang the data stascally, the difference between two groups was not found significant and there was no significant effect on maternal health except rise in maternal pulse a er half an hour of magnesium sulphate administraon which later on seled.

Conclusion: The present study suggests that neither there was significant effect of magnesium sulphate in delaying preterm birth nor there was any effect on maternal health.

Keywords: Magnesium sulphate; Tocolyc; Preterm; Neuroprotecve