An Observational Study to Evaluate the Follicular and Endometrial Response in Couples with Unexplained Infertility Undergoing Micronised Clomifene Citrate - Stimulated Intrauterine Insemination

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Dr. Aswathy Kumaran
Dr. Pratap Kumar


Background: For the couple with unexplained infertility, the choice of treatment is intrauterine insemination (IUI) coupled with superovulation because of being economical and better success rate. Ovulation done with clomifene citrate (CC) has shown good results in achieving pregnancy.

Objective: This study was conducted to assess the pregnancy rate with micronised CC (Ovagen, Walter Bushnell Pvt. Ltd., India) stimulated IUI protocol in unexplained infertility cases.

Materials and methods: A total of 50 couples with history of infertility were screened based on the inclusion and exclusion criteria of the study. All women were treated with micronised clomifene citrate 50 mg orally.

Results: Out of those 50 women, 7 (14%) conceived. Out of these 7 women, 6 (15%) women had received CC 50 mg and one (10%) woman received CC 100 mg. Out of 7 women who conceived, 5 (71.45%) had live birth, 2 (28.5%) women had miscarriage and 1 (14.3%) out of 7 had ectopic pregnancy.

Conclusion: Ovarian stimulation with micronised clomifene citrate resulted in satisfactory multifollicular development in women with unexplained infertility undergoing stimulated and triggered IUI cycles.

Keywords: Unexplained infertility; Micronised CC; IUI; Superovulation

Published May 22, 2020

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