MATERNAL SERUMS LIPIDS IN PREECLAMPSIA

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Dr. Suman Dath S
Dr. Suman Lata Mendiratta
Dr. Jasmine Chawla
Dr. Rajiv Ranjan
Dr. Meenakshi Mittal

Abstract

Background: Preeclampsia represents one of the most frequent complications of pregnancy. There is physiological hyperlipidemia which leads to increase in serum levels of triglycerides and cholesterol in pregnancy. Abnormal lipid profile is associated with endothelial dysfunction. This study was conducted to evaluate the plasma level of lipids and its association with severity of preeclampsia.



Materials and methods: A case-control study was conducted in 240 women with 120 women each in study and control group. Control group consisted of 120 normotensive pregnant women and study group consisted of 120 preeclamptic pregnant women. Serum lipid profile was estimated in both study and control group by fully automated ERBA xL-300 Biochemistry analyzer and statistical analysis was done by SPSS version 21.0.



Results: In our study, maternal serum lipids were significantly deranged in pre-eclamptic group than compared to normal pregnant women and the results were significant. We also found that women with severe preeclampsia had highly deranged lipid profile as compared to women with mild preeclampsia.



Conclusion: Preeclampsia is a common medical disorder of human pregnancy, complicating about 5-10% of all pregnancies. Deranged lipid profile levels are risk factor for endothelial dysfunction and vascular disease.


Keywords: Preeclmapsia; Triglycerides (TG); Low-density lipoproteins (LDL); High-density lipoprotein (HDL); Total cholesterol (TC)

Published Jan 11, 2020

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