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Background: There are conﬂicting evidences whether hypovitaminosis D in pregnancy is associated with hypertension and preeclampsia. In our study, we evaluated whether deﬁciency of vitamin D in maternal serum is independently associated with an increased risk of development of preeclampsia in the third trimester of pregnancy.
Materials and methods: The study enrolled 100 pregnant women. These subjects were divided into two groups: 78 subjects in Group A (Control group i.e. pregnant women without evidences of pre-eclampsia) and 22 subjects in Group B (Cases i.e. pregnant women with evidences of preeclampsia).
Results: Between the two comparable groups, we found that 11 (14.1%) subjects in the group A (control) had abnormal vitamin D level where as 17(77.3%) subjects had abnormal vitamin D level in group B (cases) and that was also statistically signiﬁcant.
Discussion: Maternal vitamin D deﬁciency in early pregnancy, deﬁned as 25(OH)-D <30 ng/ml, may be an independent risk factor for preeclampsia and vitamin D supplementation during pregnancy may be a simple step to reduce the risk of undesired pregnancy outcome.
Keywords: Vitamin D supplementation; Preeclampsia; Pregnancy