Study of Association of Decreased Maternal Serum 25 - Hydroxy Vitamin D Level and the Development of Preeclampsia in Pregnant Women Attending a Tertiary Care Referral Hospital in Kolkata

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Dr. Shouvik Das
Dr. Pallab Kumar Mistri
Dr. Bandana Biswas


Background: There are conflicting evidences whether hypovitaminosis D in pregnancy is associated with hypertension and preeclampsia. In our study, we evaluated whether deficiency of vitamin D in maternal serum is independently associated with an increased risk of development of preeclampsia in the third trimester of pregnancy.

Materials and methods: The study enrolled 100 pregnant women. These subjects were divided into two groups: 78 subjects in Group A (Control group i.e. pregnant women without evidences of pre-eclampsia) and 22 subjects in Group B (Cases i.e. pregnant women with evidences of preeclampsia).

Results: Between the two comparable groups, we found that 11 (14.1%) subjects in the group A (control) had abnormal vitamin D level where as 17(77.3%) subjects had abnormal vitamin D level in group B (cases) and that was also statistically significant.

Discussion: Maternal vitamin D deficiency in early pregnancy, defined as 25(OH)-D <30 ng/ml, may be an independent risk factor for preeclampsia and vitamin D supplementation during pregnancy may be a simple step to reduce the risk of undesired pregnancy outcome.

Keywords: Vitamin D supplementation; Preeclampsia; Pregnancy

Published Oct 17, 2019

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