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Objective: To observe serial changes in platelet indices in hypertensive pregnancies, find correlation with increasing severity of preeclampsia (PE) and determine the potential value of indices in predicting the onset and severity of PE. The effects of changing platelet indices in PE on foeto-maternal outcome were another aim.
Materials & Methods: Hundred pregnant women between 20 to 24 weeks of gestation confirmed by ultrasound, with PE of different severity, and matched healthy normotensive pregnant women served as case (n=50) and controls (n=50) respectively. Women with essential hypertension, diabetes mellitus, renal disorder, liver disorder, epilepsy, urinary tract infection and use of drugs affecting coagulation were excluded. Blood samples for platelet indices were analysed. Patients were serially sampled and observed at four weeks interval till delivery. Foeto-maternal outcome was noted.
Observations & Results: In case group majority were nullipara (66%). All platelet indices were found deranged in PE group. Platelet count decreased significantly from 2.07+0.30 l/cmm on first visit to 1.33+0.71l/cmm before delivery while platelet distribution width (PDW) and mean platelet volume (MPV) increased from14.26 to17.08 and 10.47fl to 12.6 fl respectively. MPV increased significantly with increasing PE severity (P ?0.05), it was significantly higher in cases with poor foetal or maternal outcome.
Conclusion: Platelet indices can play a significant role in earlier identification of PE and signal intervention to prevent future complications. MPV among three indices was found to be more sensitive than others to be linked to foeto-maternal outcome.
Keywords: Preeclampsia; Platelet distribution width; Mean platelet volume