ROLE OF SERUM RETINOL BINDING PROTEIN 4 IN PREECLAMPSIA: A CASE CONTROL STUDY

Dr. Uma Kumari Meena, Dr. Sandhya Jain, Dr. Neelam B. Vaid, Dr. Abha Sharma, Dr. Sonia Chawla, Dr. Kiran Guleria, Dr. Mohit Mehndiratta

Abstract


Abstract

Introduction:Preeclampsia (PE) is one of the most common and serious pregnancy related disorders. The exact etiology is still unclear. Considering inflammatory endothelial cell dysfunction as prime cause of PE, role of Retinol binding protein4(RBP4) as an inflammatory marker has been explored in few studies, but the results have not been consistent. This study was designed as case control study to evaluate the role of RBP4 in the pathophysiology of PE in Indian population.

Materials&Methods:In this case control study, a total of 150 women were finally recruited. The study group comprised of antenatal women with PE, with or without FGR (n=75) and control group included normotensive antenatal women, with appropriate for gestational age (AGA) neonates (n=75). Serum retinol binding protein levels were measured and compared between two groups.

Results:There was no significant difference in maternal serum RBP4 levels in cases of preeclampsia and healthy pregnant women with AGA neonates. On comparing mild v/s severe cases of PE with FGR and with controls, significantly lower levels were seen in mild PE with FGR as compared to severe PE and controls. On comparing all cases of PE with FGR and without FGR, significantly lower levels were seen in FGR group.

Conclusion:It is too early to comment upon the role of maternal RBP4 in the pathophysiology of preeclampsia and its clinical outcome. Larger studies are required to investigate the role of RBP4.

Keyword: Preeclampsia; Retinol Binding Protein 4; Foetal growth restriction (FGR); Adipokines


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