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Fibromyalgia syndrome (FMS) is a chronic, non-inflammatory pain syndrome characterized by diffuse myalgia and tenderness. Fibromyalgia is typically associated with sleep disturbance, fatigue, anxiety, depression, and morning stiffness and often occurs concomitantly with other conditions such as irritable bowel syndrome and headaches. This is a disorder of unknown etiopathogenesis and affects women around 9-10 times more often than men. The higher frequency of fibromyalgia particularly in women strongly suggests that sex hormones may have a role in the expression of this disease. Further there are a number of reports about varying levels of sex hormones in patients with fibromyalgia. This review addresses the status of sex hormones observed at different menstrual phases in fibromyalgia patients and their comparison with healthy subjects.
Keywords: Chronic Pain, Luteinizing Hormone, Follicle Stimulating Hormone, Estrogen, Progesterone.