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I am delighted to write the Editor's Desk for this very special issue of the Indian Obstetrics and Gynaecology (IOG) Journal as this edition features special editorial on 'Intrahepatic Cholestasis of Pregnancy-The Riddle Revisited Once Again'. This exclusive special editorial is written by Professor Enrique Oyarzun, Pontificia Universidad Catolica de Chile, who is also the International Advisory Board Member of IOG journal. Professor Oyarzun has an excellent academic career and was a part of Coronis Trial on caesarean section, conducted by Oxford University funded by MRC, UK and published in 'The lancet'.
Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy characterized by an elevation in circulating bile acids, derangement of liver function with adverse feotal outcome like preterm labour and stillbirth although in this review the risk of still birth has not been determined and was found to be similar to risk in the general population. Diseased patients have a defect involving the excretion of bile salts, which leads to raised serum bile acids. These get deposited within the skin, causing severe pruritus. Laboratory studies along with physical examination and symptoms make a diagnosis of ICP. The author has reviewed the available data, especially in consideration to the experience that his country, Chile, accumulated years ago. The esteemed readers will be immensely benefitted from this article by Professor Enrique Oyarzun.
We have an original study on 'Study of vitamin B12 deficiency in pregnancy and its impact on the maternal and foetal outcome' by Dr. Anupama Dave, Dr. Monica Verma, Dr. Neelam Jain and Dr. Atisha Dave from MGM Medical College, Indore. Vitamin B12 deficiency in reproductive age of women poses a vast impact on their obstetric profile. This study has revealed that there is causal relation between low vitamin B12 level and adverse maternal and neonatal outcome. This article also guides the readers to emphasize on the levels of vitamin B12 and its impact on pregnancy; it's maternal & foetal outcomes and presence of complications.
We have an interesting case reports on 'Twin pregnancy with single foetal demise- two case reports' by Dr. Madhu Jain and Dr. Gayatri Satpathy & 'Pheochromocytoma crisis induced by antenatal glucocorticoids in undiagnosed Men II A â€“ A case report' by Dr. JL Baidya, Dr. J Ray and Dr. A K Rakshit from Agartala Government Medical College, Agartala, Tripura which should interest and guide the readers in managing such cases in their practice. Dr. JL Baidya is a regular contributor of quality case reports and studies in the field of obstetrics to our journal.
This issue also has an interesting and clinically useful study on 'Study of incidence, causes and outcome of management of primary amenorrhoea ' by Dr. Ratnam Andallu and Dr. Sandhya Dixit from Osmania Medical College, Hyderabad. Primary amenorrhoea is an extremely stressful problem for a young girl and her parents and may lead to anxiety, depression and suicidal tendency in the affected individuals. Authors have suggested that, with the appropriate medical and surgical management, sexual, menstrual functions and occasionally even reproductive functions can be established.
Dr. Sangeeta Rai, Dr. Shreya Thapa, Dr Royana Singh and Dr. Shashikant Patne from Banaras Hindu University (BHU) have contributed an interesting case report on 'An atypical aggressive presentation of a malignant endodermal sinus tumour in a young girl - A case report'. The readers will find the case report very useful and informative in their practice.
We have a very interesting oncological case report, 'Clinical, radiological and pathological correlation of omental extra-ovarian peritoneal serous papillary carcinoma (EPSPC)-A case report' by Dr. Bhushan M Warpe, Dr. Shweta S Joshi from BKL Walawalkar Rural Medical College, Maharashtra. The authors aimed to create awareness of this rare clinical condition.
We have a very excellent review article on 'Management of vault prolapse' by Dr. Amita Jain, Medanta-The Medicity Hospital, Gurgaon, Haryana. The author has suggested that the management of such cases should be individualised, taking into consideration the surgeon's experience, patient's age, comorbidities, previous surgery and the level of physical and sexual activity.
I wish our esteemed readers a happy reading and welcome their comments & quality articles for the IOG Journal.
Dr J B Sharma